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替格瑞洛和阿司匹林治疗动脉粥样硬化性脑卒中的效果比较 被引量:2

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摘要 目的比较替格瑞洛与阿司匹林治疗动脉粥样硬化性脑卒中的效果。方法选取长垣县中医院2015年1月至2016年6月收治的87例动脉粥样硬化性脑卒中患者,依据治疗方案分为研究组(44例)和对照组(43例),给予对照组阿司匹林治疗,给予研究组替格瑞洛治疗,两组均持续治疗1个月。比较两组治疗前后血小板聚集率;统计两组临床效果、不良反应发生率及心血管事件发生率。结果治疗后,两组血小板聚集率均较治疗前降低,且研究组低于对照组,差异有统计学意义(P均<0.05);研究组临床效果优于对照组,差异有统计学意义(P<0.05);研究组不良反应总发生率为2.27%,低于对照组20.93%,差异有统计学意义(P<0.05);研究组心血管事件总发生率为9.09%,低于对照组32.56%,差异有统计学意义(P<0.05)。结论替格瑞洛治疗动脉粥样硬化性脑卒中较阿司匹林疗效更显著、抗血小板作用更强、安全性更高。
作者 翟永超
出处 《河南医学研究》 CAS 2017年第24期4498-4499,共2页 Henan Medical Research
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  • 1ANDERSON S D, SHAH N K, YIM J, et al. Efficacy and safety of ticagrelor: a reversible P2Y12 receptor antagonist [ J ]. Ann Pharmacother, 2010, 44(3): 524-537.
  • 2STEG P G, HARRINGTON R A, EMANUELSSON H, et al. Stent thrombosis with tieagrelor versus elopidogrel in patients with acute coronary syndromes: an analysis from the prospective,randomized PLATO trial [J]. Circulation, 2013, 128(10) : 1055-1065.
  • 3LEVINE G N, BATES E R, BLANKENSHIP J C, et al. 2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention:a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions[J]. J Am Coll of Cardiol, 2011, 58(24) : e44- e122.
  • 4ANDERSON J L, ADAMS C D, ANTMAN E M, et al. 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction : a report of the Amcrcian College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines [ J ]. J Am Coll Cardiol, 2013, 61(23): 179-347.
  • 5Wallentin L,Becker RC,Budaj A,et al.Ticagrelor versus clopidogrel in patients with acute coronary syndromes.N Engl J Med.2009,361:1045-1057.
  • 6Wallentin L,Becker RC,Budaj A,et al.Ticagrelor versus clopidogrel in patients with acute coronary syndromes.N Engl J Med.2009,361:1045-1057.
  • 7Mehran R,Pocock SJ,Stone GW,et al.Associations of major bleeding and myocardial infarction with the incidence and timing of mortality in patients presenting with non-ST-elevation acute coronary syndromes:a risk model from the ACUITY trial.Eur Heart J,2009,30:1457-1466.
  • 8Ducrocq G,Schulte PJ,Becker RC,et al.Association of spontaneous and procedure-related bleeds with short-and long-term mortality after acute coronary syndromes:an analysis from the PLATO trial.Eur Interv,2015,11:737-745.
  • 9Geisler T,Langer H,Wydymus M,et al.Low response to clopidogrel is associated with cardiovascular outcome after coronary stent implantation.Eur Heart J,2006,27:2420-2425.
  • 10Subherwal S, Bach RG, Chen AY, et al. Baseline risk of major bleeding in non-ST-segment-elevation myocardial infarction: the CRUSADE(Can rapid risk stratification of unstable angina pa- tients suppress adverse outcomes with early implementation of the ACC / AHA Guidelines) Bleeding Score. Circulation ,2009,119 : 1873 - 1882.

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