以聚乙二醇-聚己内酯为载体的靶向药物递送系统研究进展

Advances of Targeted Drug Delivery Based on PEG-PCL

近年来,生物可降解材料具有优异的生物可降解性能、良好的生物相容性和力学性能,在医药领域具有广阔的应用前景。两亲性聚乙二醇-聚己内酯(poly(ethylene glycol)-poly(ε-caprolactone),PEG-PCL)二嵌段共聚物作为药物递送载体的研究也逐步深入。在PEG-PCL系统表面修饰多种配体,如多肽、抗体、碳水化合物、核酸适体以及小分子等,可以显著增强药物的生物利用度和治疗效果,实现靶向给药。该文对以PEG-PCL为载体,不同配体介导的靶向递药研究进行综述,以期为PEG-PCL载体在靶向递药系统中的应用提供思路和方法。

In recent years ,biodegradable materials have been widely used in pharmaceutical field because of the excellent biodegradability,biocompatibility and mechanical property. Among them, poly （ethylene glycol）-poly （e-caprolactone） copolymers （PEG-PCL） has been widely used in drug delivery system. The drug delivery system based on PEG-PCL can be modified with various ligands, such as peptides, antibodies, carbohydrates, aptamers and small molecules for enhancing the bioavailability and therapeutic effect, achieving targeted drug delivery. In this paper,the research progress of targeted drug delivery based on PEG-PCL is reviewed, in order to provide ideas and methods for the applications of PEG-PCL in targeted drug delivery system.