摘要
目的研究小酸浆Physalis minima全草中甾体类化学成分。方法利用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、中压ODS柱色谱及半制备高效液相色谱等方法分离纯化,根据理化常数和核磁共振谱、质谱等光谱数据鉴定化合物结构。结果从小酸浆全草的乙醇提取物中分离得到7个甾体类化学成分,其中酸浆苦素类化合物2个,分别鉴定为16,24-cyclo-13,14-secoergost-2-ene-18,26-dioicacid-14:17,14:27-diepoxy-5α,6β,13α,20α,22β,25β-hexahydroxy-1,15-dioxo-γ-lactone-δ-lactone(1)、酸浆苦素D(2);醉茄内酯类化合物5个,分别鉴定为physagulin L(3)、physagulin M(4)、physaminimin F(5)、physagulin K(6)、withagulatin A(7)。结论化合物1为新化合物,命名为25-羟基酸浆苦素D;化合物3、4、7为首次从该植物中分离得到。
Objective To investigate the steroidal chemical constituents from the whole plants of Physalis minima. Methods The chemical constituents were isolated and purified by repeated silica gel column chromatography, Sephadex LH-20 gel column chromatography, medium pressure ODS column chromatography and semi-preparative HPLC, and their structures were elucidated on the basis of physico-chemical properties and spectral analysis. Results Seven compounds were separated from the whole plant of P. minima, among them, two compounds were identified as physalins and named as 16,24-cyclo-13,14-secoergost-2-ene-18,26-dioicacid-14:17,14:27-diepoxy-5α,6β,13α,20α,22β,25β-hexahydroxy-1,15-dioxo-γ-lactone-δ-lactone(1) and physalin D(2); The other five compounds were identified as withanlides and named as physagulin L(3), physagulin M(4), physaminimin F(5), physagulin K(6), and withagulatin A(7). Conclusion Compound 1 is a new compound named 25-hydroxy-physalin D, at the same time, compounds 3, 4, and 7 were obtained from this plant for the first time.
出处
《中草药》
CAS
CSCD
北大核心
2018年第1期62-68,共7页
Chinese Traditional and Herbal Drugs
基金
安徽省高等学校自然科学基金重点项目(KJ2017A768)