不同饮酒量对脂肪肝患者肝功能和糖代谢的影响

The effects of different alcohol consumptions on liver function and glucose metabolism in fatty liver patients

目的:比较不同饮酒量对脂肪肝患者肝功能和糖代谢的影响。方法:选取体检中心、门诊及病房确诊为脂肪肝的患者,根据饮酒量分为不饮酒组、适量饮酒组、过量饮酒组,比较患者一般情况、肝功能指标和糖代谢指标。结果:共收集207例脂肪肝患者,其中适量饮酒组62例,不饮酒组75例,过量饮酒组70例。适量饮酒组收缩压显著低于另外2组,舒张压显著低于过量饮酒组,体质量指数(BMI)及腰臀比(WHR)低于另外2组(P<0.05)。适量饮酒组丙氨酸转氨酶(ALT)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)低于另外2组(P<0.05),高密度脂蛋白(HDL-C)高于另外2组(P<0.05)。适量饮酒组糖化血红蛋白(HbA1c)、HOMA-IR低于另外2组(P<0.05),胰岛素作用指数(IAI)高于另外2组(P<0.05)。结论:脂肪肝患者适量饮酒可以从血压、BMI、WHR、肝功能、心血管、胰岛素抵抗等方面获益。

Objective： To compare the effects of different alcohol consumptions on liver function and glucose metabolism in fatty liver patients. Methods： The patients diagnosed with fatty liver from physical examination center, outpatient services and inpatient department, were divided into 3 groups： non-drinking group, modest-drinking group and heavy-drinking group according to the amount of alcohol consuming. Then, the details of patients＇ information include general physical condition, liver function and glucometabolic index were compared. Results： A total of 75 non-drinking patients, 62 modest-drinking patients, 70 heavy-drinking patients were collected. The modest-drinking group had a significantly lower level of systolic blood pressure （SBP） compared with other two groups and a significantly lower level diastolic blood pressure （DBP） compared with heavy-drinking group （P〈0.05）. In the comparison of body mass index （BMI） and waist-hip ratio （WHR）, the modest-drinking group was the smallest （P〈0.05）. The modest-drinking group had significantly lower alanine transaminase （ALT）, total cholesterol （TC）, triglyceride （TG）, low-density lipoprotein cholesterol （LDL-C） and significantly higher high-density lipoprotein cholesterol （HDL-C） than those of other two groups （P〈0.05）. The modest-drinking group had significantly lower hemoglobin A1c （HbA1c） and homeostasis model assessment-insulin resistance （HOMA-IR）, significantly higher insulin action index （IAI） than other two groups （P〈0.05）. Conclusion： Compared with the patients of non-drinking group and heavy-drinking group, the patients in modest-drinking group could benefit from blood pressure, BMI, WHR, liver function, cardiovascular system, insulin resistance and so on.