内镜下磁压榨胃肠造瘘应用于动物模型的探讨

A study for application of endoscopic magnetic compression gastrointestinal anastomosis in animal model

目的内镜下将磁压榨技术应用于比格犬为动物模型行胃肠造瘘术,对其操作技术进行探讨。方法采用经口内镜下引入环形母磁铁至比格犬空肠,在X线下确定母磁铁位置,然后根据位置于相对应的腹壁外放置一磁力更大的方形磁铁,使腹壁外磁铁锚定母磁铁后,退出胃镜,同样方法内镜下引入子磁铁于胃内,在X线下确定母磁铁,移去锚定磁铁,使子磁铁尽可能靠近母磁铁,胃腔及肠腔的磁铁相互吸引,并采用X线进一步证实两者相互吸引吻合。结果内镜下以比格犬为实验动物模型成功完成胃空肠造瘘术。分别于术后第3天、术后1周复查胃镜,造瘘口通畅性良好,磁铁于术后第8天完整排出体外。结论内镜下磁压榨胃肠造瘘可行、安全有效,创伤小,但操作过程中受磁场干扰大,需设计出更有利于传送释放磁铁且不干扰手术操作的系统装置。

Objective To discuss endoscopic magnetic compression technology applied in Beagle dogs for animal model of gastrointestinal nastomosis.Methods In this experiment, ring mother magnet was introduced to jejunum by peroral endoscopic and was identified the location through X-ray. Then according to the location which was corresponded to abdominal wall, a strong square magnet WAS was placed to anchor the mother magnet. With the same method, a sub-magnet was introduced by endoscopic in the stomach, using the X-ray identified the location of the mother magnet. Then the anchor magnet was removed so that the sub-magnet was as close as possible to the mother magnet, and also stomach magnet and intestine magnet were attracted to each other.Results In the endoscopy, gastrointestinal nastomosis on the Beagle dogs for animal model was successfully completed. It was found that gastrointestinal anastomosis had a good patency by endoscopy 3 days and a week after operation. The magnets were completely excluded from the body 8 days after operation.Conclusion Endoscopic magnetic compression technology is suitable, safe, minimally invasive and effective. But the technology can be influenced largely by magnetic disturbance in the operation. So it is necessary to design a system device which is more advantageous for transmitting the release magnet without interfering with the operation.