摘要
用 HPLC 法测定了地尔硫片剂在健康志愿者体内的血药浓度,其从血清的绝对回收率约为72%。其最低检测限为5ng/ml。比较了国产和日本生产的两种片剂(30mg/片)在人体的相对生物利用度,结果的统计学处理表明,两者主要参数无显著差异。
The serum concentration of diltiazem in human was determinedby HPLC.The absolute recovery from serum was about 72%.The detection limitof the method was 5ng/ml.The bioavailability of China-made diltiazem tabletswas compared with the imported ones to give results of no significant difference.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1991年第4期159-161,共3页
Chinese Journal of Pharmaceuticals
