瞬时受体电位通道在代谢综合征中的研究进展

The Progress of Transient Receptor Potential Channels in Metabolic Syndrome

瞬时受体电位(transient receptor potential,TRP)通道是由30多个非选择性阳离子通道组成的,包括7个亚家族,是由六个跨膜域和一个假定的孔隙区域组成,它们在胞质端氨基和羧基末端。各个亚型在代谢综合征中都发挥不同的作用。蛋白质、脂肪、碳水化合物等物质发生代谢紊乱会引起一系列疾病,如肥胖、高血压、糖尿病、动脉粥样硬化、骨和矿物质紊乱、电解质紊乱、炎症反应和癌症。该文综述瞬时受体电位通道在代谢综合征中的发展和作用。

The transient receptor potential （TRP） channel superfamily is composed of more than 30 nonselective cation channels. TRP channels are grouped into 7 subfamilies. TRP channel subunits contain six hydrophobic stretches and a putative amino and carboxyl terminal pore area on the cytoplasmic side. Various subtypes play an important role in the metabolic syndrome. Protein, fat, carbohydrates-related metabolic disorders can cause a series of disease, such as obesity, hypertension, diabetes, atherosclerosis, bone and mineral disorders, electrolyte disturbances, inflammatory reaction and cancer. This paper reviews the development and the role of TRP channels in the metabolic syndrome.