桃红四物汤化学成分及药理作用研究进展

Advances on Chemical Constituents and Pharmacological Effects of Taohongsiwu Decoction

桃红四物汤是活血化瘀、养血补血的代表方,在临床上有非常广泛的应用,常用于血瘀引起的多种病症。目前,关于桃红四物汤活血化瘀、调经镇痛、促进骨折愈合、抗炎、提高免疫力等研究已取得一定进展。近年来又有人对其他作用如抗疲劳、耐缺氧、补充微量元素、抗氧化损伤、神经保护等方面进行了研究。桃红四物汤的药理作用取决于其化学成分,主要为藁本内酯、阿魏酸、绿原酸、咖啡酸、没食子酸、芍药苷、梓醇、苦杏仁苷、羟基红花黄色素A、当归多糖、地黄多糖等。该文对桃红四物汤的化学成分及药理作用进行综述。

Taohongsiwu Decoction（THSWD）,the representative prescription of nourishing blood,promoting blood circulation and removing blood stasis,is widely used in clinic,and commonly used in many kinds of diseases caused by blood stasis. At present,Taohongsiwu Decoction is found to exert multiple pharmacological effects,including promoting blood circulation removing,blood stasis,regulating menstruation,promoting fracture healing,anti-inflammatory,improving immunity,and so on. In recent years,some studies have been carried out on other effects,such as anti fatigue,hypoxia tolerance,trace elements supplement,antioxidant damage and neuroprotection. The pharmacological effects of Taohongsiwu Decoction depend on its chemical compositions which mainly contain ligustilide,ferulic acid,chlorogenic acid,caffeic acid,gallic acid,paeoniflorin,catalpol,amygdalin,hydroxysafflor yellow A,angelica polysaccharide and rehmannia polysaccharide,etc. In order to further study of Taohongsiwu Decoction,its chemical constituents and pharmacological effects are reviewed in this report.