中介素1-53与高血压颈动脉粥样硬化斑块形成之间的相关性

Correlation of intermedin 1-53 with hypertension and formation of carotid atherosclerotic plaques

目的探讨中介素1-53与高血压颈动脉粥样硬化斑块形成之间的相关性。方法随机收集在本院就诊的1~2级高血压患者138例,进行颈动脉超声检查,根据结果分为斑块组98例和无斑块组40例,另选同期健康体检者30例为对照组,分别检测血浆中介素1-53水平,比较各组血压、颈动脉内膜中层厚度(cIMT)及中介素1-53水平。结果斑块组和无斑块组患者的诊室收缩压[(158.57±13.55)mm Hg、(145.16±14.54)mm Hg vs(125.24±10.64)mm Hg,1mm Hg=0.133kPa]、舒张压[(95.23±5.62)mm Hg、(87.15±4.72)mm Hg vs(80.31±4.62)mm Hg]、cIMT[(1.26±0.38)mm、(1.05±0.28)mmvs(0.87±0.38)mm]及中介素1-53水平[(7.20±1.62)ng/L、(5.05±1.85)ng/L vs(3.06±1.01)ng/L]高于对照组(P<0.05,P<0.01),且斑块组患者中介素1-53水平较无斑块组更高,差异有统计学意义(P<0.01)。结论中介素1-53可能参与颈动脉粥样硬化斑块的形成,有抵抗或延缓颈动脉粥样硬化斑块形成的作用。

Objective To study the correlation between intermedin 1-53（IMD 1-53）with hypertension and formation of carotid atheromatous plaques.Methods One hundred and thirty-eight patients with 1-2 degree hypertension admitted to our hospital for carotid ultrasonography were divided into atheromatous plaques group（n=98）and atheromatous plaques-free group（n=40）with30 subjects undergoing physical examination served as a control group in this study.Their serum IMD 1-53 level,blood pressure,and carotid IMT were measured and compared.Results The SBP[（158.57±13.55）mmHg and（145.16±14.54）mmHg vs（125.24±10.64）mmHg,1 mmHg=0.133 kPa],DBP[（95.23±5.62）mmHg and（87.15±4.72）mmHg vs（80.31±4.62）mmHg]and carotid IMT[（1.26±0.38）mm and（1.05±0.28）mmvs（0.87±0.38）mm]and serum IMD1-53 level（7.20±1.62 ng/L vs 5.05±1.85 ng/L,P〈0.01）were significantly higher in atheromatous plaques group and atheromatous plaques-free group than in control group and in atheromatous plaques group than in atheromatous plaques-free group.Conclusion IMD 1-53 is involved in the formation of carotid atheromatous plaques and can resist or delay the formation of carotid atheromatous plaques.