摘要
目的:研究BMPR2在子痫前期(PE)患者胎盘组织中的表达。方法:收集2017年1月至2017年6月于唐山市工人医院行剖宫产分娩的PE患者40例,其中轻度PE 14例,重度PE 26例。同期选取29例行剖宫产分娩的正常孕妇作为正常妊娠组。应用HE染色、免疫组化、Western blot法检测BMPR2在胎盘组织中的表达。结果:与对照组比较,PE组胎盘组织中BMPR2表达明显下降,差异有统计学意义(P<0.05)。与轻度PE组比较,重度PE组胎盘组织中BMPR2表达明显下降,差异有统计学意义(P<0.05)。结论:BMPR2在妊娠期妇女胎盘组织中有不同程度表达,在PE患者胎盘中表达降低,且随着病情加重,表达逐渐降低,其可能与PE的发生、发展有关。
Objective： To study the expression of BMPR2 in placenta of pre-eclampsia.Methods： Collected 40 samples of patients of pre-eclampsia which deliver by cesarean section in hospital from Jan.to June of 2017 and divided them into 2 groups as PE groups（ 14 samples mid PE and 26 samples serious PE）. 29 samples of patients delivered by cesarean section in hospital at the same time as normal group.The expression level of BMPR2 in placenta was detected by HE,immunohistochemistry（ IHC） and Western blot. Resulsts： The expression of protein BMPR2 in PE groups was reduced significantly compared with the normal group（ P〈0.05）.There was significantly difference in BMPR2 expression between mid and serious PE group（ P〈0.05）.Conclusions： BMPR2 is expressed in different degree in placenta of pregnant women.The expression of BMPR2 is decreased in the placenta of pregnant women with pre-eclampsia. And with the aggravation of the disease,the expression of BMPR2 gradually decreases.It may be related to the occurrence and development of pre-eclampsia.
出处
《现代妇产科进展》
CSCD
北大核心
2018年第1期6-8,13,共4页
Progress in Obstetrics and Gynecology
