四君子汤复方多糖肠道免疫调节作用及其机制研究进展

Research progress on intestinal immunoregulation and mechanism of Sijunzi Decoction polysaccharide

四君子汤复方多糖是四君子汤中含量最多的成分,具有肠道免疫调节作用。研究证实其在小肠派式结、肠系膜淋巴结、小肠上皮细胞及肠上皮内淋巴细胞等部位均能产生免疫应答,但作用机制不明。目前主要认为四君子汤复方多糖可以通过调节肠道菌群和多胺信号通路等发挥肠道免疫作用。总结近年四君子汤复方多糖对肠道免疫调节作用及其机制的相关研究进展,为深入探究四君子汤复方多糖的免疫作用机制及其临床的合理应用提供参考。

Sijunzi Decoction polysaccharide （SJZDP） is the active component contributing to the function of intestinal immunoregulation, which is the highest content in Sijunzi Decoction. SJZDP can activate immunological response in peyer＇s patch, mesenteric lymph nodes, intestinal epithelial cells and intestinal intraepithelial lymphocytes, but the mechanism is unknown. The reported mechanisms of SJZDP＇s intestinal immunoregulation activity are related to its regulation of intestinal flora and polyamine signaling pathway. This review is to give a comprehensive summary of information regarding the intestinal immunoregulation of SJZDP and mechanism to help us take the action for reasonable clinical utilization and further researches.