不稳定型心绞痛的NT-proBNP表达及其影响因素分析

Expression and Influencing Factors of NT-proBNP of Unstable Angina

目的探讨左室功能正常的不稳定型心绞痛患者血清氨基酸末端脑钠肽前体(NT-proBNP)表达及其影响因素。方法选取我院2015年10月—2016年12月收治的142例左室功能正常的心绞痛患者为研究对象,其中不稳定型心绞痛89例,稳定型心绞痛53例,另选35例健康体检者为对照组,分别对3组NT-proBNP水平进行检测,并分析NT-proBNP的影响因素。结果 3组患者NT-proBNP水平显示,不稳定型心绞痛患者明显高于稳定型心绞痛与对照组,稳定型心绞痛NT-proBNP水平较对照组高,差异均有统计学意义(P<0.05)。经多因素回归分析显示,年龄、心房纤颤、冠脉造影阳性是影响NT-proBNP水平的主要因素,冠脉造影阳性影响最大(OR值=0.214,P=0.000),心房纤颤(OR值=0.961,P=0.001)及年龄(OR值=0.581,P=0.000)其次。结论左室功能正常的不稳定型心绞痛患者NT-proBNP水平显著高于稳定型心绞痛与健康人,冠脉造影阳性、心房纤颤、年龄是NT-proBNP水平上升的独立预测因子。

Objective To investigate the expression and influencing factors of serum N-terminal pro brain natriuretic peptide( NT-pro BNP) of patients with normal left ventricular function and unstable angina pectoris. Methods 142 cases of angina( 89 cases of unstable angina and 53 cases of stable angina) with normal left ventricular function,who accepted treatments in our hospital from October 2015 to December 2016,were included in the study. Another 35 cases of healthy people taking health examination were selected as the control group. The levels of NT-proBNP of the three groups were detected,and the factors of NT-proBNP were analyzed. Results The level of NT-proBNP of the patients with unstable angina were significantly higher than whose with stable angina and the control group,and the level of NT-pro BNP of the patients with stable angina was statistically higher than that in the control group( P < 0. 05). According to the multivariate regression,age,atrial fibrillation and positive coronary angiography were the main factors affecting the level of NT-proBNP,among which positive coronary angiography was the largest( OR = 0. 214,P = 0. 000),followed by Atrial fibrillation( OR = 0. 961,P = 0. 001) and age( OR = 0. 581,P = 0. 000). Conclusion The level of NT-proBNP of unstable angina patients with normal left ventricular function are significantly higher than that of stable angina patients and healthy population. The positive coronary angiography,atrial fibrillation,and age are independent predictors of the increasing level of NT-proBNP.