白细胞介素-32与疾病关系的研究进展

Advances in the study of the relationship between interleukin-32 and diseases

白细胞介素-32(IL-32)是2005年发现的一种细胞因子,它有六种剪接变异体分别为IL-32α、IL-32β、IL-32γ、IL-32δ、IL-32ε和IL-32ζ。IL-32与肿瘤坏死因子-α(TNF-α)、IL-6等细胞因子一样在炎症及自身免疫性疾病中高表达。本文主要对IL-32的生物学作用以及与结核病、肿瘤及自身免疫性疾病如炎性肠病、类风湿性关节炎(RA)等疾病关系进行了综述。

Interleukin-32（IL-32）is a cytokine that was discovered in 2005.IL-32 has six subtypes：IL-32α,IL-32β,IL-32γ,IL-32δ,IL-32ε,and IL-32ζ.IL-32 is,along with TNF-αand IL-6,over-expressed in inflammatory and autoimmune diseases.This paper summarizes the biological functions of IL-32 in tuberculosis,tumors,inflammatory diseases,and autoimmune diseases.IL-32 may protect a host from a variety of diseases,which is why its mechanism of action is being studied.