补肾益气安神方剂治疗来曲唑诱导的PCOS大鼠的实验研究

A study on treating PCOS rats induced by letrozole with the Bushen Yiqi Anshen prescription

目的:探讨补肾益气安神方剂在来曲唑诱导的PCOS模型大鼠治疗过程中的作用。方法:采用来曲唑诱导法建立PCOS大鼠模型40例,给予达英-35作阳性对照组、给予补肾益气安神方剂为治疗组。比较治疗前后各组大鼠血清中E2、P、FSH、LH、T、FPG、FINS、HOMA-IR水平的变化。结果:与治疗前相比,治疗后两组大鼠血清E2、P水平明显升高(P<0.05),LH、T、FSH、FPG、FINS较治疗前明显降低。经统计学分析,治疗后两组的E2、LH比较,差异均有统计学意义(P<0.05)。治疗后两组的P、T、FSH、FPG、FINS、HOMA-IR比较,差异无统计学意义(P>0.05)。结论:补肾益气安神方剂对PCOS胰岛素抵抗大鼠的疗效确切,本方通过调节内分泌,使卵巢血流量增加,胰岛素抵抗得到改善,胰岛素效应得到增强,从而促使卵泡发育、诱发排卵。

Objective To investigate the role of the Bushen Yiqi Anshen prescription on PCOS rats induced by letrozole. Methods： 40 cases of PCOS model were established by letrozole and divided into 2 groups. The control group was given Diane-35; the treatment group was treated with the Bushen Yiqi Anshen prescription. The changes of serum E2, P, FSH, LH, T, FPG, FINS in groups were compared. Results： After treatment, serum E2 and P levels in groups were signifcantly increased （P〈0.05）; LH, T, FSH and FINS were signifcantly lower. There were signifcant diferences in the levels of E2 and LH between groups. There was no signifcant diference in serum P, T, FSH, FPG, FINS, HOMA-IR between groups. Conclusion： The Bushen Yiqi Anshen prescription on PCOS rats is efective, can regulate endocrine, increase ovarian blood fow, improve the insulin resistance and efects, promote follicular development, and induce ovulation.