胰岛素针重复应用的安全性Meta分析

Safety of repeated use of insulin pen-needles:a Meta-analysis

目的胰岛素注射在治疗糖尿病中的功效取决于正确的注射技术。比较胰岛素针重复使用和非重复使用在糖尿病患者中的安全性,并为患者提供此方面的指导。方法我们搜索PubMed,Embase,Cochrane图书馆和中国知网的研究,比较胰岛素针的重复使用与非重复使用在糖尿病患者中的安全性。结果共纳入了7项研究,包括18 204例患者。与胰岛素针非重复使用组相比,胰岛素针重复应用增加了皮下脂肪增生的风险[OR=2.28,95%CI(1.77,2.94)],Meta回归结果为异质性产生的原因可能为胰岛素注射针更换频率和糖尿病类型之间的差异。结论我们的研究得出有力的证据支持胰岛素针重复应用可能会增加皮下脂肪增生的风险,胰岛素针应该单次使用。

Objective The effect of insulin injection in the treatment of diabetes depends on the correct technique of injection.To compare the safety of insulin pen-needle reuse and non-reuse in diabetic patients,and to provide guidance to patients in this area.Methods We searched Pub Med,Embase,the Cochrane library and CNKI to compare the safety of insulin pen-needle reuse and non-reuse in diabetic patients.Results Seven studies were included,including 18204 patients.Compared with insulin pen-needle non-reuse group,insulin pen-needle reuse increased the risk of subcutaneous flipohypertrophy [OR =2.28,95% CI（1.77,2.94）].The heterogeneity of the meta-regression findings may be due to the differences between the frequency of insulin pen-needle replacement and types of diabetes.Conclusion The strong evidence from our study supports that insulin pen-needle reuse may increase the risk of subcutaneous lipohypertrophy.Insulin pen-needles should be used for one time.