前列地尔治疗老年糖尿病并慢性肾脏病患者疗效和安全性观察

Observation on Curative Effect and Safety of Alprostadil in Treatment of Senile Patients with Diabetes and Chronic Renal Diseases

目的探讨前列地尔治疗老年糖尿病并慢性肾脏病患者疗效和安全性观察。方法将2015年3月—2017年6月在该院治疗的62例老年糖尿病并慢性肾脏病患者随机分为两组,对照组采用常规治疗,在此基础上观察组采用前列地尔治疗,比较两组患者的临床疗效、肾功能各指标改善情况、不良反应。结果观察组治疗有效率为93.55%,明显高于对照组的74.19%,差异有统计学意义(P<0.05);观察组治疗后BUN、Scr、UAER、e GFR、ACR与对照组相比明显改善,差异有统计学意义(P<0.05);两组均无明显不良反应发生(P>0.05)。结论前列地尔治疗老年糖尿病并慢性肾脏病的临床疗效确切,能有效改善肾功能,且无明显不良反应,具有积极的临床意义。

Objective To study the curative effect and safety of Alprostadil in treatment of senile patients with diabetes and chronic renal diseases. Methods 62 cases of senile patients with diabetes and chronic renal diseases treated in our hospital from March 2015 to June 2017 were selected and randomly divided into two groups, the control group adopted the routine therapy, while the observation group were treated with alprostadil on the basis of the control group, and the clinical curative effect, and improvement of renal function indicators, and adverse reactions were compared between the two groups. Results The treatment effective rate in the observation group was obviously higher than that in the control group（93.55% vs74.19%）, and the difference was statistically significant（P〈0.05）, after treatment, the BUN, Scr, UAER, e GFR, ACR were obviously improved compared with that in the control group, and the differences were statistically significant（P〈0.05）, and there were no obvious adverse reactions（P〉0.05）. Conclusion The clinical curative effect of alprostadil in treatment of senile patients with diabetes and chronic renal diseases is definite, which can effectively improve the renal function without obvious adverse reactions, and it is of positive clinical significance.