奥曲肽联合凝血酶治疗肝硬化合并上消化道出血的疗效分析

Analysis of Curative Effect of Octreotide and Thrombin in Treatment of Cirrhosis and Upper Gastrointestinal Hemorrhage

目的探讨肝硬化合并上消化道出血的患者使用凝血酶联合奥曲肽的治疗效果。方法随机选择2015年6月—2017年1月在该院诊治的肝硬化合并上消化道出血的患者180例,随机分为3组,每组60例,A组使用奥曲肽,B组使用凝血酶,C组使用凝血酶联合奥曲肽,观察患者的疗效,监测止血时间、住院的时间、输血量、再出血等。结果 C组的总有效率为96.67%,明显高于A组、B组,差异有统计学意义(P<0.05);C组的止血时间为(18.79±2.53)h、住院的时间为(4.11±1.52)d、输血量(201.04±48.56)m L、再出血率8.33%,C组明显优于A组、B组,差异有统计学意义(P<0.05);A组和B组的总有效率、止血时间、住院时间、输血量、再出血,差异无统计学意义(P>0.05)。结论奥曲肽和凝血酶联合使用治疗肝硬化合并上消化道出血效果较好,在临床上可广泛使用。

Objective To discuss the curative effect of octreotide and thrombin in treatment of cirrhosis and upper gastrointestinal hemorrhage. Methods 180 cases of patients with cirrhosis and upper gastrointestinal hemorrhage diagnosed in our hospital from June 2015 to January 2017 were randomly selected and randomly divided into three groups with 60 cases in each, the group A, group B and group C were respectively treated with octreotide, thrombin and the combination of octreotide and thrombin, and the curative effect, hemostasis time, length of stay, transfusion amount and rebleeding were observed. Results The total effective rate in the group C was obviously higher than that in the group A and group B, which was 96.67% in the group C, and the difference was statistically significant(P<0.05), and the hemostasis time, length of stay,transfusion amount and rebleeding in the group C were respectively(18.79±2.53)h,(4.11±1.52)d,(201.04±48.56)m L, 8.33%,which were obviously better than those in the group A and group B, and the differences were statistically significant(P <0.05), and the differences in these indexes between the group A and group B were not big without statistical significance(P>0.05). Conclusion The effect of combination of octreotide and thrombin in treatment of cirrhosis and upper gastrointestinal hemorrhage is good, which can be widely applied in clinic.