食管癌中肝细胞生长因子及其受体的表达与淋巴管生成和淋巴结转移的关系

The Expression of HGF and its Receptor c-met in Human Esophageal Carcinoma and the Relationship to Lymphangiogenesis and Lymphatic Metastasis of EC

目的:检测肝细胞生长因子(HGF)及其受体(c-met)在食管癌中的表达水平,分析其与食管癌淋巴管生成及淋巴结转移的关系。方法:采用免疫组化方法检测30例食管正常粘膜、70例食管癌组织中HGF及c-met的表达,并用D2-40标记微淋巴管,分析HGF及c-met的表达与微淋巴管密度(LMVD)及食管癌淋巴结转移间的关系。结果:食管癌组织中HGF及c-met表达及LMVD明显高于食管正常粘膜组织,并且HGF及c-met表达与食管癌微淋巴管密度及淋巴结转移呈正相关。结论:HGF及c-met在食管癌中的过表达可促进食管癌微淋巴管形成及淋巴结转移,阻断其过表达可成为食管癌治疗及预防食管癌淋巴结转移的新的研究方向。

Objective： To determin the expression of HGF and its receptor c-met in human esophageal carcinoma and to investigate the relationship between HGF and its receptor with lymphangiogenesis and lymphatic metastasis of EC. Method： Immunohistochemical staining was used to examine expression of HGF and c-met in 30 cases of NM and 70 cases of EC tissues.The microlymphatic density（ LMVD） in esophageal carcinoma was calculated by D2-40 as the specific marker of lymphatic endothelium. Results： Expression of HGF and c-met in EC showed significantly higher than that in NM,and they were positively correlated with lymphangiogenesis and lymphatic metastasis of EC. Conclusion： The overexpression of HGF and c-met may play an important role in lymphangiogenesis and lymphatic metastasis of EC.