摘要
研究帕金森病(PD)认知功能障碍患者不同时期给予多巴丝肼、普拉克索治疗前后血同型半胱氨酸(Hcy)、胱抑素C(CysC)水平与认知障碍程度之间的关系。选取93例健康对照组和97例PD患者,将PD组分为无认知障碍组、轻度认知障碍组、痴呆组。并将各亚组随机分别给予多巴丝肼、普拉克索治疗6个月。于治疗前后测定血Hcy、CysC水平,行UPDRS评分、MoCA评分、MMSE评分。PD组Hcy、CysC水平明显高于对照组,随着各亚组认知障碍加重Hcy、CysC水平呈上升趋势。多巴丝肼组Hcy水平升高,认知障碍加重,普拉克索组Hcy水平无明显变化,认知障碍无加重;两种治疗后各亚组CysC水平均有下降,普拉克索组下降明显。Hcy、CysC可能反应PD认知功能障碍程度,可作为病情及治疗效果的评定指标之一。
Study on Parkinson's disease(PD)patients with cognitive impairment in different periods given Benserazide,pramipexole before and after treatment of blood homocysteine(Hcy),cystatin C(CysC)level and the relationship between the degree of cognitive impairment.A total of 93 healthy controls and 97 PD patients,PD patients were divided into non cognitive impairment group,mild cognitive impairment group and dementia group.Each subgroup was treated with benserazide,pramipexole.Before and after treatment,serum Hcy,CysC level,UPDRS score,MoCA score,MMSE score were evaluated.PD group Hcy,CysC was significantly higher than control group,with each subgroup of cognitive impairment increase, Hcy levels increased.Benserazide treatment group increased Hcy levels,decreased cognitive impairment.Pramipexole has no significant effect on Hcy level and cognitive impairment.Pramipexole can reduce the level of Cys C.Subgroups of CysC levels were decreased,pramipexole group decreased significantly.The levels of Hcy and Cys C may reflect the degree of cognitive impairment in Parkinson's disease,which can be used as one of the indicators for assessing the disease and the effect of treatment.
出处
《医学与哲学（B）》
2018年第1期36-39,共4页
Medicine & Philosophy(B)
基金
2016年辽宁省自然科学基金项目(2016565689)
