ECP与肺炎支原体肺炎关系的研究进展

Advances in the Relationship between ECP and Mycoplasma Pneumonia

肺炎支原体肺炎(MPP)是小儿常见急性呼吸道感染性疾病,好发于学龄儿童。儿童感染肺炎支原体后常易迁延,部分病例久治难愈,表现为咳嗽或喘息发作,甚至发展为哮喘。临床研究证实,MPP患儿多存在免疫失衡现象。传统抗菌治疗可起到抑制局部炎症作用,近期疗效确切,但因无法纠正全身免疫功能失衡,易导致病情反复、迁延。因此,明确MPP患儿机体免疫平衡变化及其特点对于临床诊治和预后评估具有重要意义。通过检测MPP患儿血清嗜酸性粒细胞阳离子蛋白(ECP)水平,探讨其在支原体肺炎患儿中的临床应用价值。该文概括了ECP与MPP关系的最新研究进展。

Mycoplasma Pneumoniae Pneumonia（MPP） is a common acute respiratory infection in children. It is very common in school-age children. Children infected with Mycoplasma pneumoniae often easy to delay, some cases would be cured for a long time, with the performance of cough or wheezing, and even asthma. Clinical studies confirmed that MPP children with multiple immune imbalance phenomenon. Traditional antibacterial treatment can play a role in inhibiting local inflammation, the recent effect is exact, but becomes imbalance for not correcting systemic immune function, easily lead to repeated and persistent disease. Therefore, it is important to clarify the changes of immune balance and its characteristics in children with MPP for clinical diagnosis and treatment and prognosis. Through investigating the clinical value of serum eosinophil cationic protein（ECP） in children with MPP, its clinical value in children with mycoplasma pneumonia is explored. This paper summarizes the latest research on the relationship between ECP and MPP.