中西结合治疗溃疡性结肠炎临床疗效观察

Clinical Efficacy of Integrated Chinese and Western Medicine in the Treatment of Ulcerative Colitis

目的:观察中西结合治疗溃疡性结肠炎(Ulcerative colitis,UC)临床疗效。方法:将2015年3月—2017年2月治疗的40例UC患者作为研究对象,采用随机数表法将入选者分为两组,各20例。对照组实施美沙拉嗪治疗,观察组则加以中药内服、保留灌肠治疗。观察两组临床疗效、复发率、不良反应与治疗前后症状积分、炎性因子水平、免疫功能、Sutherland疾病活动指数(Sutherland DAI)等变化。结果:两组治疗总有效率、复发率相比,观察组优于对照组,差异有统计学意义(P<0.05);治疗前两组腹泻、腹痛、脓血便评分、肿瘤坏死因子-α(TNF-α)、白细胞介素-17(IL-17)、白细胞介素-23(IL-23)、C反应蛋白(CRP)、Sutherland DAI评分、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+对比,差异无统计学意义(P>0.05);治疗后观察组腹泻评分、腹痛评分、脓血便评分、TNF-α、IL-17、IL-23、CRP、Sutherland DAI评分、CD3^+、CD4^+、CD4^+/CD8^+均低于对照组,CD8^+高于对照组,差异有统计学意义(P<0.05);两组不良反应发生率相比,差异无统计学意义(P>0.05)。结论:中西医结合治疗UC疗效确切,利于调节炎性因子水平,改善不适症状与免疫功能,降低病情活动度,是一种治疗UC的安全有效方案。

Objective： To observe the clinical efficacy of integrated Chinese and Western medicine in the treatment of ulcerative colitis（UC）. Methods： 40 UC patients treated from March 2015 to February 2017 were divided into two groups by random number table, 20 cases in each group. Control group was given mesalazine, while observation group was treated with herbal oral administration and retention enema. The clinical efficacy, recurrence rate, adverse reactions, changes of symptoms scores, levels of inflammatory factors, immune function, Sutherland disease activity index（DAI） before and after treatment in two groups were observed. Results： The total effective rate and recurrence rate of observation group were better than those of control group（P〈0.05）; Before treatment, there was no statistical difference in the diarrhea, abdominal pain, bloody purulent stool score, tumor necrosis factor-α（TNF-α）, interleukin-17（IL-17）, interleukin-23（IL-23）, C-reactive protein（CRP）, Sutherland DAI score, CD3＋, CD4＋, CD8＋, CD4＋/CD8＋ between the two groups（P〈0.05）; After treatment, the diarrhea, abdominal pain, bloody purulent stool score, TNF-α, IL-17, IL-23, CRP, Sutherland DAI score, CD3＋, CD4＋, CD4＋/CD8＋ in observation group were lower than those in control group, while CD8＋ in observation group was higher than that in control group（P〈0.05）; There was no statistical difference in the incidence of adverse reactions between the two groups（P〉0.05）. Conclusion： Integrated Chinese and Western medicine in treatment of UC is effective, can regulate the levels of inflammatory factors, improve uncomfortable symptoms and immune function, decrease disease activity index, which is a safe and effective regimen in treatment of UC.