不同分子分型乳腺癌的自动乳腺全容积成像冠状面图像特征分析

Analysis of coronal plane imaging features of automated breast volume scanner in different molecular subtypes of breast cancer

目的探讨不同分子分型乳腺癌的自动乳腺全容积成像(ABVS)冠状面图像特征及其临床应用价值。方法分析153例(157个病灶)经病理证实的不同分子分型乳腺癌患者的ABVS冠状面图像特征及免疫组化结果。结果不同分子分型乳腺癌在ABVS冠状面上显示的边界、微钙化及间接征象差异均有统计学意义(均P<0.05),微钙化在Luminal B型和Her-2过表达型中所占比例较多(69.4%、77.3%),汇聚征在Luminal A型最常见(43.7%),三阴型更容易出现清晰的边界(27.8%)。不同分子分型的乳腺癌边缘轮廓之间差异无统计学意义。结论不同分子分型乳腺癌的ABVS冠状面图像特征各自具有一定特异性,可为乳腺癌治疗方式的选择及预后评估提供更多信息。

Objective To investigate the coronal plane imaging features of automated breast volume scanner（ABVS）in different molecular subtypes of breast cancer and its clinical application value.Methods One hundred and fifty-three breast cancer patients（157 lesions）who confirmed by pathology were enrolled.Each lesion was examined by ABVS to acquire coronal plane imaging features and by immunohistochemical analysis to obtain the molecular subtype.ABVS coronal plane imaging features of different molecular breast cancer were analyzed.Results Significant differences were found in boundary,microcalcifications and indirect signs on the coronal plane among the four subtypes（all P 0.05）.The Luminal B and Her-2 subtypes were more commonly seen with microcalcifications（69.4%,77.3%）.Retraction phenomenon occurred more frequently in Luminal A subtype（43.7%）.Clear boundary was more often found in triple-negative subtype（27.8%）.No significant difference was found in margin shape among the four subtypes.Conclusion Different molecular subtypes of breast cancer have their own specific coronal plane imaging features,which can provide more information for the treatment and prognostic evaluation.