艾滋病暴露前预防用药依从性的伦理学思考

The Ethical Reflections on Adherence of Pre-exposure Prophylaxis for AIDS

艾滋病暴露前预防用药作为一种新型预防HIV感染的方式,大量临床研究证实,它能有效减少HIV感染的风险,下一步就是将其运用于日常实践。但临床试验又表明,其有效性与受试者的依从性有着密切关联。通过讨论艾滋病暴露前预防用药依从性的伦理问题,如个人隐私权与社会公众知情权、药物不良反应、药物费用、歧视和污名化等,提出应对措施和建议,从而在保证艾滋病暴露前预防用药良好依从性的前提下,指导其更好地推广和应用。

The pre-exposure prophylaxis（PrEP）for AIDS is a new preventive drug.It can substantially decrease human immune deficiency virus（HIV）transmission,which has been approved by a large number of trials.Next step is going to put the effective PrEP from clinical trial to clinical practice.However,the trials also showed that there was a strong correlation between the effectiveness of PrEP and the participant adherence.This paper focuses on the ethical issues of adherence of PrEP,such as individual privacy and public right of notification,drug adverse event,drug expenses,discrimination and stigmatization.In the end,the suggestions are also proposed in order to promote the appropriate use of PrEP with good participant adherence.