肠道黏膜免疫细胞在食物致敏中的作用研究进展

A Review of the Role of Intestinal Mucosal Immune Cells in Food Sensitization

食物过敏是食品安全的重要问题之一,且大部分食物过敏是在胃肠道消化过程中引发的。食物过敏原蛋白经胃肠道消化后形成肽段,其中部分消化肽在通过肠上皮组织屏障进入肠道黏膜系统后,被递呈给相关免疫细胞,从而引发肠道黏膜系统中一系列免疫应答反应。本文阐述了消化肽进入肠道黏膜后,肠上皮细胞、树突状细胞、B淋巴细胞及CD4^+T淋巴细胞在黏膜免疫致敏过程中所起的作用,为探讨食物过敏引发胃肠道免疫的工作机制提供了理论依据。

Food allergy is one of the most important problems in food safety, and most food allergy events occur in the gastrointestinal tract. A series of immune responses are initiated in the gut, since some digested peptides pass through the barrier of intestinal epithelial cells and enter the intestinal mucosa, where they are presented to relevant immune cells. In this review, the roles of intestinal epithelial cells, dendritic cells, B lymphocytes and CD4~＋ T lymphocytes in the sensitization of digested peptides at the intestinal mucosa are discussed, which will provide valuable information to explore the underlying mechanisms of gastrointestinal immunity during food allergy development.