胃癌组织中S100A11、MMP-9及E-cadherin的表达及意义

Significance and expression of S100A11,MMP-9 and E-cadherin in gastric cancer

目的探讨胃癌组织中S100钙结合蛋白A11(S100A11)、基质金属蛋白酶-9(MMP-9)及E-钙黏蛋白(E-cadherin)的表达及意义。方法回顾性研究采用免疫组化法检测收集的92例胃癌组织及92例癌旁正常组织中S100A11、MMP-9及E-cadherin的表达,并分析三者与临床病理参数的关系。结果胃癌组织中S100A11、MMP-9的阳性表达率显著高于癌旁正常组织(P<0.05)。胃癌组织中E-cadherin的阳性表达率显著低于癌旁正常组织(P<0.05)。胃癌组织中S100A11、MMP-9及E-cadherin的表达与临床分期、淋巴结转移及浸润深度密切相关,而与年龄、性别无关。同时胃癌组织中S100A11、MMP-9及E-cadherin表达具有相关性。结论高表达的S100A11、MMP-9及低表达的E-cadherin对胃癌的发生发展起促进作用,可能成为胃癌诊断的判断指标。

Objective To explore significance and expression of S100 calcium-binding protein A11(S100 A11),matrixmetalloproteinase-9(MMP-9) and E-cadherin in gastric cancer.Methods The expression of S100 A11,MMP-9 and E-cadherin in 92 cases of gastric cancer and 92 cases of adjacent normal tissues were detected by immunohistochemical method.The relationship between S100 A11,MMP-9,E-cadherin and clinical pathological parameters was analyzed.Results The positive rate of S100 A11 and MMP-9 in gastric cancer was higher than that in adjacent normal tissues(P < 0.05).The positive rate of S100 A11,MMP-9 and E-cadherin were closely related with clinical stage,lymph node metastasis and depth of invasion,but not with age and sex.The positive rate of S100 A11,MMP-9 and E-cadherin in gastric cancer tissues was correlated.Conclusion Higher expression of S100 A11 and MMP-9,lower expression of E-cadherin can promote the occurrence and development of gastric cancer,and can be used as markers for the diagnosis of gastric cancer.