Goldeneye 25A身份识别系统在回族人群的法医遗传学多态性

Application of Goldeneye 25A Identification System in the HUI Population

目的调查Goldeneye 25A身份识别系统所包含的STR基因座在回族人群中的法医遗传学信息,用于指导本地区回族人群的法医学分析。方法应用Goldeneye 25A身份识别系统对湖南长沙市所采集的200名回族健康无关个体进行STR基因座分型检测,统计分析STR基因座的频率数据及法医学参数信息。结果 Goldeneye 25A身份识别系统中包含的23个常染色体STR基因座在回族人群中均符合Hardy-Weinberg平衡(H-W平衡),基因座之间相互独立,累积个体识别概率为1-6.88×10^(-29),累积非父排除概率为1-7.67×10^(-11)。其中含有的DYS391基因座在回族人群中的基因变异度为0.4547,父权排除概率为0.4524。结论 Goldeneye 25A身份识别系统中含有的STR基因座在回族人群中具有良好的多态性,可应用于法医实际检案及相关科研工作中。

Objective To investigate the genetic information of STRs included in Goldeneye 25A Identification system in the local HUI population. Methods By genotyping and analyzing 200 unrelated healthy HUI individuals with Goldeneye 25A Identification system,allelic frequencies and forensic parameters information of related STRs were statistically analyzed. Results No deviations from Hardy -Weinberg equilibrium were detected at the 23 autosomal STRs and all loci were independent form each other. The combined discrimination power was 1- 6.88x 10-29,whereas the combined mean exclusion chance was 1- 7.67x 10-11. The gene diversity of DYS391 locus was 0.4547,while power of exclusion paternity was 0.4524. Conclusion The included STRs of Goldeneye 25A Identification system are polymorphic in HUI population and can be adopted in forensic case work and research studies.