太芪培元颗粒对气阴两虚肺肾不足型HIV感染者TLR-4影响的研究

Effect of Taiqipeiyuan Granules on TLR-4 Receptor of HIV-infected Patients Who were Deficency of both Qi-yin and Lung-kidney

目的:观察太芪培元颗粒对气阴两虚肺肾不足型CD4+T淋巴细胞>350个·u L-1的HIV感染者的临床疗效。方法:采用队列研究,将108例HIV感染者根据是否服用太芪培元颗粒分为暴露组及非暴露组。观察6个月,对比两组患者的CD4+T淋巴细胞、HIV-RNA病毒载量、中医症状体征积分、Toll样受体-4(toll like receptor-4,TLR-4)、白介素-10(IL-10)等指标的差异。结果:经过6个月的治疗,暴露组比非暴露组的中医症状体征积分、TLR-4受体指标变化差异有统计学意义(P<0.05)。CD4^+T淋巴细胞、HIV-RNA病毒载量、IL-10等指标差异无统计学意义(P>0.05)。结论:运用太芪培元颗粒治疗气阴两虚肺肾不足型CD4^+T淋巴细胞>350个·u L^(-1)HIV的感染者,可以改善患者临床症状,稳定患者CD4+T淋巴细胞计数,抑制TLR-4受体。太芪培元颗粒可能是通过机体免疫调节的过程发挥作用。

Objective: To observe the curative effect of taiqipeiyuan granules to HIV-infected patients with CD4+T lymphocytes >350 ·μL-1,who were deficiency of both qi-yin and lung-kidney. Methods: One hundred and eight HIV-infected patients in this cohort study were divided into two groups as exposure group and non-exposed group according to whether taking taiqipeiyuan granules. The exposure group was taking taiqipeiyuan granules,the non-exposed group without taking taiqipeiyuan granules. After 6 months,to observe the difference between two groups of patients with CD4^+T lymphocytes,HIV-RNA viral load,TCM symptom score,TLR-4 receptor,IL-10 and other indicators. Results: After 6 months of treatment,the difference between the two groups in TCM symptom score and TLR-4 receptor were statistically significant( P < 0. 05). The difference between the two groups in CD4^+T cells,HIV-RNA viral load,IL-10 and so on were not statistically significant. Conclusion: Taiqipeiyuan granules can improve the clinical symptoms of HIV-infected patients with CD4^+T lymphocytes > 350 ·u L^(-1),stabilize CD4^+T lymphocyte count and inhibit TLR-4 receptor. Taiqipeiyuan granules may play a role in regulating the immune process.