甘氨双唑钠联合放射治疗宫颈肿瘤疗效观察

Clinical efficacy observation of sodium glycididazole combined with radiotherapy for cervical neoplasms

目的:观察甘氨双唑钠联合放射治疗宫颈肿瘤的临床疗效。方法:选取80例宫颈肿瘤患者为研究对象,按照随机数表法平均分为对照组和观察组,每组40例,对照组采用常规的放射治疗,观察组在对照组基础上联合甘氨双唑钠进行治疗,比较两组患者的治疗效果以及不良反应发生情况。结果:观察组患者的治疗有效率明显高于对照组患者(P<0.05)。在不良反应发生方面,两组对比差异无统计学意义(P>0.05)。观察组患者达到完全缓解所需的照射剂量为(3 453.7±785.9)c GY,达到部分缓解所需的照射剂量为(2 209.5±688.4)c GY;对照组患者达到完全缓解所需的照射剂量为(4 862.6±643.8)c GY,达到部分缓解所需的照射剂量为(3 769.0±616.4)c GY,两组患者之间有明显差异(P<0.05)。结论:在对患有宫颈肿瘤的患者进行治疗时,采取甘氨双唑钠联合放射治疗能取得更好的治疗效果,可有效控制局部肿瘤的病变,不良反应小,是一种理想的宫颈肿瘤治疗方式。

Objective To study clinical efficacy of sodium glycididazole combined with radiotherapy for cervical neoplasms.Methods： Eighty patients with cervical neoplasms were selected as the subjects, and were divided into two groups according to the random number table method. Among them, 40 patients in the control group were treated with conventional radiotherapy, while 40 patientsin the observation group were treated with sodium glycididazole on the basis of the control group. The therapeutic effects and the adverse reactions of the two groups were analyzed and compared. Results： The effective rate in the observation group was significantlyhigher than that in the control group （P〈0. 05）. There was no statistically significant difference between the two groups in the adverseevents （P〉0. 05）. Thedoses required for partial remission and complete remission in the observation group were （2209. 5±688. 4）cGY and （3453. 7±785. 9） cGY, those in the control group were （3769. 0±616. 4） cGY and （4862. 6±643. 8） cGY, and the differences were significant （P〈0. 05）. Conclusions： In the treatment of the patients with cervical cancer, sodium glycididazolecombinedwith radiotherapycan achieve better therapeutic effects, and can effectively control the patients＇ local tumor lesions with less adverse reactions. Therefore, it is an ideal way to treat cervical neoplasms.