脑梗死患者抗血小板药物抵抗的发生率及相关因素研究

Study on the Incidence and Related Factors of Antiplatelet Drug Resistance in Patients With Cerebral Infarction

目的探讨脑梗死患者阿司匹林抵抗(AR)与氯吡格雷抵抗(CR)发生率及相关因素。方法选取我院于2013年5月—2016年9月收治的147例脑梗死患者,A组98例患者予以阿司匹林肠溶片口服治疗,B组49例予以氯吡格雷片口服治疗,7 d后对全部患者血小板聚集率进行测定,确认患者药物抵抗发生例数,并对相关因素进行分析。结果服药7 d后,A组药物抵抗共发生43例,发生率43.88%;B组CR发生11例,发生率22.45%。经分析后发现药物抵抗发生与患者年龄密切相关,CR发生与患者自身患有糖尿病关联密切。结论脑梗死发病人群中存在阿司匹林抵抗及氯吡格雷抵抗发生情况,高龄极有可能是阿司匹林抵抗发生的主要因素,糖尿病则可能为CR发生的主要因素。

Objective To investigate the incidence and related factors of aspirin resistance （AR） and clopidogrel resistance （CR） in patients with cerebral infarction. Methods A total of 147 patients with cerebral infarction admitted in our hospital from May 2013 to September 2016 were enrolled in this study. 98 patients in group A were treated with aspirin enteric-coated tablets and 49 patients in group B were treated with clopidogrel tablets. After 7 days, the platelet aggregation rate was measured in all patients. The number of cases of AR and CR was confrmed, and the related factors were analyzed. Results After 7 days of treatment, 43 cases （43.88%） of drug resistance occurred in group A, group B received 11 cases of CR with a rate of 22.45%. The analysis found that drug resistance is closely related with the age of patients, CR patients with their own diabetes are closely linked. Conclusion There are AR and CR in the population of cerebral infarction,and it is very likely that the elderly is the main factor of AR. Diabetes may be the main factor of CR.