氯吡格雷抵抗研究进展

Research Progress in Clopidogrel Resistance

氯吡格雷(clopidogrel)是目前世界范围内广泛应用的抗血小板药物,在急性冠脉综合征和经皮冠状动脉介入术患者的治疗中发挥重要作用,可有效降低血小板的活性,降低支架内血栓形成的发生率,进而减少心血管疾病的发生风险。但部分患者服用氯吡格雷后仍会发生冠脉血栓事件,此种现象被称为氯吡格雷抵抗或氯吡格雷无反应、低反应。早期识别氯吡格雷抵抗对于预防心血管不良事件的发生有重要意义。该文通过综述氯吡格雷抵抗的定义、发生机制及实验室评估方法,为氯吡格雷抵抗的临床处理提供指导。

Clopidogrel is one of the anti-platelet drugs,which is widely used in the world.It plays an important role in the treatment of patients with acute coronary syndrome and those undergoing percutaneous coronary intervention.Clopidogrel is effective in inhibiting the activity of platelets,decreasing the incidence of thrombosis in the stent,and then reducing the risk of adverse cardiovascular events in affected individuals.However,some patients still have coronary thrombosis after taking clopidogrel.This phenomenon is known as clopidogrel resistance or clopidogrel non-response or low response.Identification of clopidogrel resistance is of great significance in preventing the occurrence of adverse cardiovascular events.This paper provides guidance for the clinical treatment of clopidogrel resistance by discussing the definition,mechanisms and laboratory evaluation of clopidogrel resistance.