外源性磷酸肌酸心肌保护多靶作用机制的研究进展

Research Progress in Multiple Target Action Mechanisms of Myocardium of Exogenous Phosphocreatine

磷酸肌酸(phosphocreatine,PCr)为一种天然高能磷酸化合物,在维护机体能量自稳态中发挥关键作用。外源性PCr已作为心肌保护药广泛用于心血管疾病的治疗中。其结构独特,蕴藏较多生物学信息,为一多靶指向药物。21世纪以来,由于分子生物学的迅速发展,其多靶作用机制不断得到阐明,除能量相关机制外,还包括非能量相关机制,不仅涉及胞内机制,而且涉及胞外机制。该文根据笔者多年研究以及查阅国内外文献,对其多靶作用机制研究进展,包括能量提供、膜稳定化、抗血小板聚集、电生理学、酶抑制以及线粒体保护与抗凋亡作用等方面进行综述。

Phosphocreatine(PCr),a natural high energy phosphate,plays a pivotal role in maintaining energy homeostasis of the body.Exogenous PCr has been developed as a cardio-protective drug and extensively used in treatment of cardiovascular diseases.PCr has special chemical structure,which confers much bioinformation on it,and becomes a multitargetdirected drug.Since the 21st century,with rapid development of molecular biology,the multiple target action mechanisms of PCr have continually gained elucidation,including energy-related and non-energy-related mechanisms,intracellular and extracellular mechanisms,which are leading to its extensive clinical applications in cardiovascular diseases.Based on author's research and published literatures,this article reviews the research progress in multiple target action mechanisms of PCr,including energy supply,membrane stabilization,anti-platelet aggregation,electrophysiology,enzyme inhibition and protection of mitochondria,antiapoptotic effect,etc.