艾司西酞普兰不良反应文献分析

Literature Analysis of Escitalopram Adverse Reactions

目的了解艾司西酞普兰不良反应发生情况及注意事项。方法计算机检索万方数据库、中国知网、Pubmed数据库有关艾司西酞普兰不良反应,重点分析发生不良反应的患者性别、年龄、临床表现、累及系统等。结果收集文献31篇,共纳入患者31例,艾司西酞普兰不良反应发生男女比例相当,不良反应发生在用药后几小时至6个月,累及器官系统较多,包括神经系统、循环系统、内分泌系统、消化系统、生殖系统、运动系统等。结论艾司西酞普兰使用应遵医嘱,不宜随意加量,定期监测不良反应,确保临床合理用药。

Objective To investigate the adverse drug reactions(ADRs) induced by escitalopram and precautions.Methods Wanfang,CNKI,Pubmed databases were searched to retrieve information about escitalopram adverse reactions reported in the literature,focusing on analysis of adverse reactions in patients with age,sex,clinical manifestations,involved systems,etc.Results Totally,31 references were collected,and a total of 31 cases included in the review analysis.The adverse reaction rate was equivalent between the male and the female.The adverse reaction occurred a few hours to 6 months after medication,and it involved several organ systems,including the nervous system,circulatory system,endocrine system,alimentary system,urinary system,kinetic system,etc.Conclusion Escitalopram should be used according to the doctor's advice,and its amount should not be arbitrarily added.Regular monitoring of adverse reactions should be performed to ensure rational use of the drug.