三花益肾汤对子宫内膜异位症患者血清IL-6、TNF-a水平影响研究

Effect of Sanhua Yishen Decoction on Serum IL-6 and TNF-a Levels in Patients with Endometriosis

目的:探讨三花益肾汤对子宫内膜异位患者血清IL-6、TNF-a的水平影响及效果观察。方法:将某院收诊的子宫内膜异位症患者48例,按照就诊先后顺序,随机分为对照组(24例)与治疗组(24例),对照组给予西药丹那唑口服治疗,治疗组给予三花益肾汤中药方剂治疗,两组治疗过程均不少于30d,采用放射免疫分析法检测两组患者血清浓度及分别观察两组子宫内膜异位症患者腹腔液中血清IL-6、TNF-a的水平变化。结果:两组经治疗后,治疗组总有效率为91.6%,对照组总有效率为66.6%,差异有统计学意义(P<0.05);两组患者经30d治疗后治疗组在血清浓度及腹腔液中IL-6、TNF-a的水平明显高于对照组,差异有统计学意义(P<0.05)。结论:经疗效对比,西药丹那唑与三花益肾汤比较,三花益肾汤能双向调节抑制子宫内膜局部的炎症反应,减轻异位细胞因子的分泌及自身增殖,预后效果显著,防止复发。

Objective:To investigate the effect of Sanhua Yishen decoction on serum IL-6 and TNF-a levels in patients with endometriosis.Methods:48 patients with endometriosis admitted to a hospital were randomly divided into control group(24 cases)and treatment group(24 cases)according to the order of treatment.The control group was given the oral dendazol treatment,and the treatment Group was given Sanhua Yishen decoction treatment,the course of treatment in both groups was not less than 30 days,then the serum concentration of two groups were were measured by radioimmunoassay and the serum levels of IL-6 and TNF-a in peritoneal fluid of patients with endometriosis were observed.Results:After treatment,the total effective rate was 91.6%in the treatment group and 66.6%in the control group,the difference was statistically significant(P<0.05).After treatment for 30 days,the levels of IL-6 and TNF-a were significantly higher in the treatment group than those in the control group,and the difference is statistically significant(P<0.05).Conclusion:Compared with danazol,Sanhua Yishen decoction can regulate the inflammation of endometrium in two directions,and reduce the secretion and autoproliferation of odorous cytokines,which the prognosis is significant and can prevent recurrence.