系统性红斑狼疮患者血清维生素D水平的变化意义

The implications of serum Vitamin D levels in patients with systemic lupus erythematosus

目的分析和探讨系统性红斑狼疮(SLE)患者血清维生素D水平的变化意义。方法选取2016年8月至2017年8月我院治疗的74例SLE患者和66名健康志愿者作为研究对象,通过收集其血标本,后使用酶联免疫吸附试验检测其血清25-羟基维生素D_3(25-OH-D_3)、维生素D抗体(VD-Ab)、1,25-二羟基D_3[1,25(OH)_2D_3]水平,比较2组的差异性,并行Spearman相关性分析。结果 SLE组的血清25-OH-D_3、VD-Ab、1,25(OH)_2D_3水平均显著低于健康对照组(P均<0.05),SLE患者的血清25-OH-D_3和1,25(OH)_2D_3呈正相关(r=3.95,P=0.045),其血清25-OH-D_3和VD-Ab水平、VD-Ab和1,25(OH)_2D_3均无显著相关性(P均>0.05)。结论 SLE患者的血清维生素D水平较健康人群显著低下,血清维生素D在SLE的病情发展中扮演重要角色,具有潜在治疗价值。

Objective To analyze and explore the significance of serum vitamin D in patients with systemic lupus erythematosus(SLE). Methods Seventy-four SLE patients and 66 healthy volunteers who were treated in our hospital from August 2016 to August 2017 were selected as subjects. After collecting blood samples,the serum 25-OH-D_3,VDAb,1,25(OH)_2D_3levels was detected by enzyme-linked immunosorbent assay,differences were compared between the two groups,and the Spearman correlation analysis was performed. Results Serum levels of 25-OH-D_3,VD-Ab,1,25(OH)_2D_3in SLE group were significantly lower than those in healthy control group(P <0.05),There was a positive correlation between serum 25-OH-D_3 and 1,25(OH)_2D_3in patients with SLE(r =3.95,P =0.045),and there was no significant correlation between serum 25-OH-D_3 and VD-Ab levels,VD-Ab,VD-Ab& 和 1,25(OH)_2D_3(P >0.05).Conclusion Serum vitamin D level in SLE patients is significantly lower than that in healthy people. Serum vitamin D plays an important role in the development of SLE,and It has potential therapeutic value.