GHK三肽的最新研究进展

On Latest Research Progress of the GHK Tripeptide

GHK(glycyl-L-histidyl-L-lysine)存在于人的血液、唾液、尿液当中并随着年龄的增长下降。通常GHK是与2价铜离子作为复合物来发挥促愈合和修复的功能。GHK可以调节胶原和糖胺聚糖的合成与分解,并且调节金属蛋白酶和它的抑制剂的活性。它刺激胶原、硫酸皮肤塑、硫酸几丁质、小糖蛋白、糖蛋白的合成,它同样能够恢复经过放化疗的成纤维细胞的再生能力。这种分子可以吸引免疫细胞和内皮细胞向受伤部位迁移。它加速皮肤、毛囊、胃肠道、骨组织,和狗的脚垫伤口愈合,它同样可以诱导大鼠、小鼠和猪的全身伤口愈合。在美容产品当中,它能够让松弛的皮肤紧实,并增加弹性,皮肤的密度和坚实度,减少细纹和皱纹,减少光损伤和色素沉着,增加角质形成细胞的增殖。已经证明GHK可以作为治疗性成分在慢性阻塞性肺炎和代谢性癌症中应用。GHK可以上调或者下调至少4000种人类基因,尤其在DNA恢复重建当中发挥重要作用。文章主要关注GHK在皮肤再生领域的最新进展。

GHK （glycyl-L-histidyl-L-lysine） is present in human blood, saliva and urine and decreases with age. In general,GHK acts as a complex with bivalent copper ions to promote healing and repair. GHK regulates the synthesis and decomposition ofcollagen and glycosaminoglycan, and the activity of metalloproteinases and its inhibitors. It stimulates the synthesis of collagen, sulphuric acid skin plastic, chitin sulfate, glycoprotein and glycoprotein, and it can also restore the regeneration ability of fibroblasts after radiotherapy and chemotherapy. This molecule can attract immune cells and endothelial cells to move to the injured site. Itspeeds the healing of skin, hair follicles, gastrointestinal tract, bone tissue, and dog foot pads. It also induces the healing of wholebody wounds in rats, mice and pigs. In beauty products, it compacts the loose skin and increases elasticity, density and firmness ofthe skin, reduces fine lines and wrinkles, reduces light damage, and pigmentation, and increases the proliferation of keratinocytes. Ithas been shown that GHK can be used as a therapeutic component in chronic obstructive pneumonia and metabolic cancer. GHKcan up-regulate or down-regulate at least 4,000 human genes, especially in the recovery and reconstruction of DNA. This review focuses on the latest development of GHK in the field of skin regeneration.