自身抗体在自身免疫性疾病患者中的检查价值研究

Study on the value of autoantibodies in patients with autoimmune diseases

目的探讨自身抗体在自身免疫性疾病患者中的检查价值。方法选取2014年1月~2015年1月在我院就诊的80例AID(自身免疫性疾病患者)作为研究对象,检测患者血清中的ANA(抗核抗体)和ENA(可抗提取性抗原抗体)的阳性状况,计算阳性预测值PV,对提取患者的ANA和ENA做荧光分型分析。结果 ANA阳性患者为31例,阴性患者为9例,患者PV值为0.78;ENA阳性患者为32例,阴性患者为8例,患者PV值为0.80,两种抗体的阳性例数差异无统计学意义(P>0.05),PV值差异有统计学意义(P<0.05)。80例不同种类AID患者的ANA抗体荧光分型显示均质型和核颗粒型较为显著,ENA抗体荧光分型主要以核少颗粒性以及少点型为主。结论可以通过测定患者抗体的阴阳性以及荧光分型来对自身免疫性疾病进行鉴定。

Objective To investigate the value of autoantibodies in patients with autoimmune diseases. Methods 80 cases of AID （autoimmune disease patients） in our hospital from January 2014 to January 2015 were selected as the research objects.The positive status of ANA （anti nuclear antibody） and ENA （anti extractive antigen antibody） in the serum of patients were detected,and the positive predictive value of PV was calculated.The fluorescence typing of ANA and ENA extracted from patients were analyzed. Results There were 31 cases of ANA positive patients and 9 cases with negative patients.the PV value of the patients was 0.78.There were 32 cases of ENA positive patients and 8 cases with negative patients.the PV value of the patients was 0.80.There was no significant difference in the number of positive cases of two kinds of antibodies （P 〉0.05）,and there was significant difference in PV values （P 〈0.05）.The ANA antibody fluorescence typing of 80 AIDS patients with different types showed that homogeneous type and nuclear particle type were more significant.The fluorescent typing of ENA antibody was mainly characterized by less particle type and less point type. Conclusion Autoimmune diseases can be identified by measuring the negative and positive of the patient＇s antibodies and fluorescence typing.