钙结合蛋白S100A12水平与慢性阻塞性肺疾病急性加重期患者严重程度的相关性

Correlation between calcium-binding protein S100A12 level and severity of patients with chronic obstructive pulmonary disease in acute exacerbation

目的探讨血清钙结合蛋白S100A12水平与慢性阻塞性肺疾病急性加重期(AECOPD)病情严重程度的关系及其在AECOPD严重程度中的诊断价值。方法选取2016年11月至2017年2月在甘肃省人民医院呼吸科住院的AECOPD患者40例,并以同期健康体检者20例作为对照。收集AECOPD患者就诊当天及治疗缓解后出院前天空腹检测的超敏C反应蛋白(hs-CRP)、降钙素原(PCT)值,应用酶联免疫吸附法(ELISA)检测入组当天及治疗后出院前天血清钙结合蛋白S100A12水平。结果 AECOPD组治疗前血清钙结合蛋白S100A12水平显著高于治疗后(P<0.05),且高于健康对照组(P<0.05);AECOPD组治疗前血清钙结合蛋白S100A12水平与hs-CRP、PCT呈正相关(r=0.414,P<0.01;r=0.326,P<0.05),治疗后与hs-CRP、PCT无相关性。结论钙结合蛋白S100A12水平可用作AECOPD病情严重程度的评估及诊断指标。

Objective To investigate the relationship between serum calcium binding protein S100 A12 level and the severity of chronic obstructive pulmonary disease in acute exacerbation(AECOPD)and its diagnostic value.Methods From November 2016 to February 2017,40 patients with AECOPD hospitalized were enrolled and 20 healthy subjects were enrolled as controls.The hs-CRP and procalcitonin(PCT)values of AECOPD patients on the day of treatment and on the day before discharge hs-CRP were collected.The level of serum calcium binding protein S100 A12 was detected by enzyme-linked immunosorbent assay(ELISA).Results Before treatment,the serum level of S100 A12 in AECOPD group was significantly higher than that in healthy controls(P <0.05),and after treatment,the serum level of S100 A12 in AECOPD group was significantly lower than that in healthy controls(P <0.05).Before treatment,the level of S100 A12 in AECOPD group showed a positive correlation with hs-CRP and PCT(r=0.414,P<0.01;r =0.326,P <0.05).There was no correlation between S100 A12,hs-CRP and PCT after treatment.Conclusion The level of calcium binding protein S100 A12 can be used as an indicator in AECOPD severity assessment and diagnosis.