阻塞性睡眠呼吸暂停低通气综合征对甲状腺功能的影响

Influence of obstructive sleep apnea hypopnea syndrome on thyroid function

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)对甲状腺功能的影响。方法回顾性分析2015年1月至2016年2月在四川大学华西医院行整夜睡眠呼吸监测及甲状腺功能检查的400例住院患者,根据呼吸暂停低通气指数(AHI)水平分为非OSAHS组及OSAHS组,其中OSAHS组又进一步分为轻度OSAHS组、中度OSAHS组和重度OSAHS组,比较各组在性别、年龄、体重指数(BMI)、合并甲状腺功能减退、糖尿病或高血压的比例、甲状腺激素水平(TSH、FT3、FT4)及甲状腺相关抗体(TgAb、TPOAb)方面的差异。应用多元Logistic回归对OSAHS与甲状腺功能的关系进行分析。结果 OSAHS组的男性比例、年龄、BMI、合并糖尿病或高血压的比例均高于非OSAHS组(P<0.01)。重度OSAHS组的FT3水平略高于非OSAHS组及轻度OSAHS组(P<0.05)。非OSAHS组的TPOAb阳性率高于OSAHS组(P=0.049)。多元Logistic回归分析显示OSAHS与甲状腺功能不相关。结论 OSAHS可能对甲状腺功能无显著影响。

Objective To investigate the effect of obstructive sleep apnea hypopnea syndrome(OSAHS)on thyroid hormone function.Methods 400 hospitalized patients of West China Hospital of Sichuan University with sleep breathing monitoring and thyroid function examination were enrolled from January 2015 to February 2016.The differences in gender,age,body mass index(BMI),hypothyroidism,diabetes or hypertension,thyroid hormone levels(TSH,FT3,FT4)and thyroid associated antibodies(TgAb,TPOAb)were compared.The clinical data as well as the thyroid hormones and related antibodies were compared between the non-OSAHS and mild to severe OSAHS groups.The relationship between OSAHS and thyroid hormone levels was analyzed using binary Logistic regression analysis.Results The proportion of male,age,BMI,combined diabetes or hypertension in the OSAHS group were higher than those in the non OSAHS group(P <0.01).The level of FT3 in the severe OSAHS group was slightly higher than that of the non OSAHS group and the mild OSAHS group(P <0.05).The positive rate of TPOAb in non OSAHS group was higher than that in group OSAHS(P =0.049).The binary Logistic regression analysis showed that OSAHS was not related to the thyroid function.Conclusion OSAHS may have no effect on thyroid function.