维生素D水平与成人支气管哮喘关系的Meta分析

Association between serum vitamin D level and adult bronchial asthma:a meta-analysis

目的系统评价血清中维生素D水平与成人支气管哮喘的关系。方法计算机检索CoChrane Library,PubMed,EMbase,Web of science,OVID,Springerlink,Wiley online library,ScienceDirect,EBSCOhost,中国知网,维普数据库,万方数据库,检索建库至2017年5月1日发表的关于维生素D与成人哮喘相关性的研究。由2位研究者独立按照纳入与排除标准进行文献选择、资料提取和质量评价后,采用RevMan5.3软件进行Meta分析。结果共纳入9个研究,均为病例对照研究,包括827例患者和287例对照。Meta分析结果显示:成人哮喘组25(OH)D水平低于对照组(MD=-15.90,95%CI=-18.55^-13.25,P<0.01);成人哮喘患者比对照组更易发生维生素D不足(RR=2.03,95%CI=1.57~2.63,I2=0%,P=0.79);成人哮喘患者中维生素D不足者FEV1%水平低于维生素D正常者(MD=-9.78,95%CI=-12.21^-7.36,P<0.01)。结论维生素D水平与成人哮喘有关,哮喘患者普遍存在维生素D不足,维生素D不足与肺功能相关,维生素D不足可能是哮喘的潜在危险因素之一。

Objective To investigate the relationship between serum vitamin D level and bronchial asthma in adults.Methods We searched the CoChrane Library,PubMed,EMbase,Web of science,OVID,Springerlink,Wiley online library,ScienceDirect,EBSCOhost,CNKI,VIP,Wanfang data databases from inception to May 1 st 2017 to collect studies about the association between vitamin D and adult asthma.Two reviewers independently screened literature according to inclusion and exclusion standard,extracted data and assessed the quality of included studies.Then,meta-analysis was performed using RevMan 5.3 software.Results Nine case-control studies involving 827 asthma patients and 287 controls were finally included.The meta-analysis showed that 25(OH)D in adult asthma group was lower than that in control group(MD =-15.90,95%CI =-18.55--13.25,P <0.01).Adult asthma presented more vitamin D deficiency than the controls(RR =2.03,95%CI =1.57-2.63,I2=0%,P =0.79).In asthma patients,FEV1 % in vitamin D deficiencies was lower than that of the normal(MD =-9.78,95%CI =-12.21--7.36,P <0.01).Conclusion Vitamin D level is associated with asthma in adults.Vitamin D deficiency is common in patients with asthma and associated with lung function.The lack of vitamin D may be one of the potential risk factors for asthma.