重症急性胰腺炎合并肠动力障碍相关机制的研究进展

Research Progress in the Mechanism of Severe Acute Pancreatitis Complicated with Intestinal Dynamic Disorders

急性重症胰腺炎(SAP)为临床常见危重症之一,常导致多器官功能障碍,其中胃肠道功能障碍尤为常见。SAP合并肠动力障碍时可导致病情进一步加重,并诱发其他并发症,不利于患者的预后,影响SAP治愈率。尽早恢复肠动力是有效阻止SAP合并肠道动力障碍的患者病情加重的关键因素之一。SAP合并肠动力障碍相关机制复杂而繁多。SAP合并肠道动力障碍的原因可能与胃肠激素、神经系统、胃肠道Cajal间质细胞等有关。探索SAP合并肠道动力障碍的机制有助于指导临床诊断及治疗等。目前,SAP合并肠道动力障碍机制仍欠明确,有待进一步研究。

Severe acute pancreatitis( SAP) is one of the common critical clinical diseases,which often leads to multiorgan dysfunction,and the gastrointestinal dysfunction is particularly common. The SAP complicated with intestinal dynamic disorders can lead to aggravating condition and induce other complications,which is not conducive to the prognosis of patients,affecting the cure rate of SAP. Early recovery of intestinal motility is one of the key factors that can effectively prevent the aggravating condition of the SAP patients with gut dysfunction. The related mechanisms for SAP complicated with intestinal dynamic disorders are complex and numerous,which might include gastrointestinal hormones,nervous system and Cajal stromal cells in the gastrointestinal tract. Exploring the mechanism of SAP combined with intestinal dynamic disorders can help guide the clinical diagnosis and treatment,which is still unclear and further research is needed.