IL-12抗肿瘤作用机制的研究进展

Research Progress in Antitumor Mechanism of IL-12

细胞因子介导的免疫治疗成为肿瘤生物治疗的热点,尤以白细胞介素(IL)12为主。IL-12主要通过调节树突状细胞,自然杀伤细胞(NK)表面的受体表达;激活NK,T细胞;诱导肿瘤微环境中的巨噬细胞向M1型分化;增强肿瘤细胞自噬相关蛋白表达,诱导自噬;影响IL-10或γ干扰素的分泌,下调血管内皮生长因子及程序性死亡配体1等来影响肿瘤的生长、转移。目前关于IL-12抗肿瘤的研究主要以实验为主,将IL-12合理应用于临床将成为未来的研究方向。

Cytokine mediated immunotherapy has become a hot topic in tumor biotherapy,especially interleukin( IL)-12. IL-12 affects the growth and metastasis of tumors mainly through regulating the expression of receptors on the surface of dendritic cells and nature killer( NK) cells,activation of NK,T cells,inducing macrophages differentiation into M1 type under tumor microenvironment,enhancing expression of autophagy-associated protein in tumor cells,inducing autophagy,and affecting secretion of IL-10 or γ interferon,and downregulating vascular endothelial growth factor and programmed death ligand 1. At present,the research on anti-tumor of IL-12 is mainly based on experiments,and the reasonable application of IL-12 in clinical will become the future research direction.