拉马宁碱兔体内药物动力学和生物利用度研究

PHARMACOKINETICS AND BIOAVAILABILITY OF LEHMANNINE IN RABBITS

剂量均统一为40mg/kg 家兔静注拉马宁碱的生理盐水溶液,体内动力学符合二室开放模型,主要参数为:C_0=28.34μg/ml,α=0.077min^(-1),β=0.016 min^(-1),V=2040.73ml/kg,Cl=32.65ml/[min·kg),AUC=1225.1μg·min/(ml·kg)。口服和肌注时其动力学均符合单室模型,生物利用度分别为43.12%、104.43%。

In rabbits,having a dose of 40 mg/kg of lehmannine the drugconcentration-time curves fitted two compartment open model after iv administra-tion,one compartment open model after im and po administration,respectively.The principal pharmacokinetic parameters of iv administration were as follows:C_0=28.34μg/ml,α=0.077 min^(-1),β=0.016min^(-1);V=2040.73 ml/kg,Cl=32.65 ml/(min·kg),AUC=1225.1μg·min/(ml·kg).