传统中药槐定碱调节自噬反应的强度来治疗PKD的潜在应用

Potential Application of Sophorindine,a Tradition Chinese Medicine,in the Treatmend of ADPKD by Induce Autophagy

基本上所有的细胞都有由微管组成的原发性纤毛,主要功能是感知环境的各种信号和协调细胞内的信号通路。自噬是细胞对饥饿/炎症和感染等环境生存压力的一种适应性反应。许多纤毛性疾病都会诱导自噬反应的发生。多囊肾是最常见的纤毛疾病,全世界发病率为1∶500到1∶1 000。该病的典型症状为慢性发展的多个肾囊肿,最终发展为晚期肾病。槐定碱是从传统中草药苦豆子中得到的一种生物碱,是一种新型抗肿瘤药物,具有诱导细胞自噬的作用。主要讨论通过槐定碱诱导自噬反应治疗多囊肾的可能性。

There are primary cilium （ PC）almost in all type cells, which is consist of microtubes, andfunction as sensing the signals of surrounding environment and coordinating a variety of signallingpathways. The Autophagy is an adaptive response of cell to survive under different enviroment stress,such as serum starve, inflammation, infection and so on. Most of ciliopathies diseases induce autophagy. Polycystic kidney disease is the most common Ciliopathies, the world incidence is 1500 to 1：1 000. A typical symptom of this disease is the chronic development of multiple renal cysts that eventually develop into advanced kidney disease. Sophoridine is an alkaloid obtained from the traditionalChinese herbal medicine Sophora alopecuroides, which is a new antitumor drug with the function ofinducing autophagy. This article focuses on the possibility of sophoridineinduced autophagy in thetreatment of polycystic kidney disease.