硫酸镁联合硝苯地平治疗妊娠高血压综合征的临床效果研究

Study on clinical effect of magnesium sulfate combined with nifedipine in the treatment of gestational hypertension syndrome

目的探究硫酸镁联合硝苯地平治疗妊娠高血压综合征的临床效果。方法 40例妊娠高血压综合征产妇,根据病床单双号分为对照组和观察组,每组20例。对照组单纯应用硫酸镁进行治疗,观察组则给予硫酸镁联合硝苯地平治疗,比较两组产妇的治疗效果、血液粘度、红细胞体积以及尿蛋白定量。结果观察组产妇的总有效率为95.00%,显著高于对照组的70.00%,差异具有统计学意义(χ~2=4.3290,P<0.05)。用药治疗后,对照组产妇的血液粘度为(3.4±0.8)m Pa·s,红细胞体积为(42.6±8.9)%,尿蛋白定量为(2.4±0.7)g/24 h;观察组产妇的血液粘度为(1.9±0.5)m Pa·s,红细胞体积为(30.2±6.4)%,尿蛋白定量为(1.1±0.2)g/24 h,两组产妇的血液粘度、红细胞体积、尿蛋白定量对比差异具有统计学意义(P<0.05)。结论硫酸镁联合硝苯地平治疗妊娠高血压综合征效果显著,能够有效改善产妇的各项临床指标,提高治疗效果,值得广泛应用。

Objective To investigate the clinical effect of magnesium sulfate combined with nifedipine in the treatment of gestational hypertension syndrome. Methods A total of 40 gestational hypertension syndrome puerpera were divided by single and double number into control group and observation group, with 20 cases in each group. The control group was treated with magnesium sulfate, and the observation group was treated with magnesium sulfate combined with nifedipine. Comparison were made on treatment effect, blood viscosity, erythrocyte volume, and urine protein quantitation between the two groups. Results The observation group had obviously higher total effective rate as 95.00% than 70.00% in the control group, and the difference was statistically significant （χ2=4.3290, P〈0.05）. After medication, the control group had blood viscosity as （3.4±0.8） mPa·s, erythrocyte volume as （42.6±8.9）% and urine protein quantitation as （2.4±0.7） g/24 h, which were （1.9±0.5） mPa·s, （30.2±6.4）% and （1.1±0.2） g/24 h in observation group. Both groups had statistically significant difference in blood viscosity, erythrocyte volume, and urine protein quantitation （P〈0.05）. Conclusion Combination of magnesium sulfate and nifedipine shows remarkable effect in treating gestational hypertension syndrome, and can effectively improve all clinical indicators and treatment effect. It is worthy of wide application.