Flotillin-1的生理功能及其在疾病中的作用研究进展

Advances in Study of Physiological Function of Flotillins and its Role in Disease

Flotillin-1(浮舰蛋白-1)是脂筏的标记蛋白。它不但参与多种细胞正常的生理活动,也在许多肿瘤发生和发展中起重要作用。近年发现Flotillin-1在肺腺癌、乳腺癌、肝细胞癌等细胞中高表达,并与临床等级、预后差、总体存活率低有关联。简要综述了Flotillin的组成、结构和基本功能,以及在疾病中的作用。

Flotillin-1 is a marker protein of lipid raft. It is not only involved in a variety of normal physiological activities of cells, but also plays an important role in many tumorigenesis and development. Recently, it has been found that flotillin-1 is highly expressed in lung adenocarcinoma, breast cancer and hepatocellular carcinoma cells, and associated with clinical grade, poor clinical grade and low overall survival. We reviewed the composition, structure, and basic functions of flotillins as well as the role in the disease.