上海市静安区部分老年退休教师慢性肾脏病调查

An Epidemiological Survey of Chronic Kidney Disease in Part of Elderly Retired Teachers in Jing'an District, Shanghai

目的了解上海市静安区老年退休教师人群慢性肾脏病(chronic kidney disease,CKD)的流行状况以及常见危险因素。方法 2017年4月—10月收集上海市静安区老年退休教师体检人群共485例,其中女性235例、男性250例。用简化的肾脏病饮食调整研究公式(modification of diet in renal disease,MDRD)求出肾小球滤过率的估计值(estimated glomerular filtration rate,e GFR)作为CKD患病率评估标准。结果在本研究中,老年退休教师人群CKD的总患病率为49.48%,其中女性患病率为42.13%,男性患病率为56.40%(2=9.878,P=0.0016)。根据年龄将研究对象分为6组,其中60~64岁年龄组CKD的患病率为28.57%,到≥85岁年龄组CKD的患病率达到75.56%,平均每5岁递增7.83%。在全部CKD患者中,2期和3期所占比例较大,其中CKD2期占88.33%,CKD3期占11.67%。多因素Logistic回归分析显示年龄、血尿酸和空腹血糖为影响CKD的独立危险因素。结论上海市退休老年教师人群CKD的患病率主要集中于CKD2期和CKD3期,并随年龄增长而增长。年龄、血尿酸和空腹血糖是影响CKD的独立危险因素。

Objective To investigate the prevalence and risk factors of chronic kidney disease （CKD） in the elderly retired teachers in Jing＇an District, Shanghai. Methods A total of 485 elderly retired teachers for physical examination were collected in Jing＇an District, Shanghai during the period from April, 2017 to October, 2017, including 235 female and 250 male; the estimated glomerular filtration rate （eGFR） calculated with the modification of diet in renal disease （MDRD） formula was taken as the evaluation criteria. Results The overall prevalence of CKD in thr elderly retired teachers was 49.48%; the prevalence of CKD in female group was 42.13% while that was 56.40% inmale group （χ2=9.878, P=0.0016） ; the enrolled subjects were divided into 6 groups according to age; the prevalence of CKD was 28.57% in the 60-year-old group and 75.56% in the 85-year-old group; an average increase for every 5 years was 7.83%; stage 2 and 3 of CKD took up a large proportion in all the elderly with CKD （ 88.33% of stage 2 and 11.67% of stage 3）; Multivariate Logistic Regression Analysis showed that age, serum uric acid, and glucose were independent factors of CKD. Conclusions Most o f the retired teachers with CKD in Jing＇an District, Shanghai, are at stage 2 and 3, the prevalence of CKD increases with age; age, serum uric acid and glucose are independent factors of CKD.