摘要
目的探讨血清Betatrophin水平与GDM的相关性及其临床意义。方法选取2015年10月至2016年8月于昆山市第一人民医院产科门诊产前检查的孕妇110名,其中GDM患者(GDM组)53例,正常妊娠者(GNGT组)57名,ELISA检测两组Betatrophin水平,同时检测血糖、HbA1c、血脂等指标。结果 GDM组血清Betatrophin水平高于GNGT组(P<0.05)。相关性分析显示,GDM组血清Betatrophin水平与年龄及HbA1c呈正相关,年龄及HbA1c是血清Betatrophin水平的独立影响因素。Logistic回归分析显示,血清Betatrophin是GDM的影响因素(P<0.05)。结论 GDM患者血清Betatrophin水平增高,提示Betatrophin可能参与了GDM的发生发展。
Objective To investigate the association between serum Betatrophin levels andgestational diabetes mellitus(GDM),and to evaluate its value on clinical application.Methods A total of 110 pregnant women with GDM(GDM group,n=53)or without GDM(NGT group,n=57)were enrolled from Oct 2015 to Aug 2016 in our hospital.Serum Betatrophin was measured using ELISA method.HbA1c,blood glucose and lipids were also tested and compared.Results The Betatrophin levels were significantly higher in GDM group than in NGT group [1700.36(995.98,2501.06)vs1359.63(880.71,1947.87)(pg/ml),P〈0.05].The correlation analysis revealed that serum Betatrophin levels in GDM group were positively associated with age and HbA1c.Logistic regression showed that serum Betatrophin was positively correlated with the incidence of GDM.Conclusion GDM women had significantly higher Betatrophin levels in comparison with NGT women which indicated that Betatrophin may be involved in the development of GDM.
作者
卢冰
王苏
洪霞飞
钟绍
潘颖
方玲娜
张莉
沈莉雯
蒋娜
王济芳
王东
袁国跃
LU Bing;WANG Su;Hong Xia fei;et al(Department of Endocrinology, Affiliated KunshanHospital of Jiangsu University, Kunshan 215300, China)
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2018年第1期46-49,共4页
Chinese Journal of Diabetes
基金
国家自然科学基金面上项目(81570721
81370965)
江苏省自然基金科学资助项目(BK20151331
BK2009208)
江苏省卫生厅国际交流支撑计划及面上科技项目(H201247)
"六大人才高峰"第十二批高层次人才项目(2015-WSN-006)
江苏省高层次卫生人才"六个一"工程项目(LGY2016053)
镇江市科技支撑-社会发展重点项目(SH2015028)
2016年度苏州市临床重点病重点诊疗技术专项项目(LCZX201620)
江苏大学2016年度医学临床科技发展基金(JLY20160063)
昆山市社会发展科技专项(KS1666)