阿尔茨海默病营养状态与认知功能的相关性研究

The relationship between nutritional status and cognitive function in Alzheimer's disease

目的:探探讨阿尔茨海默病(AD)病人的营养状况及与认知功能之间的关系,以了解AD病人的营养状况,同时为临床医师干预其营养状况提供理论支持。方法:选取老年神经科住院AD病人60例,正常老年人对照组50例,采用实验室检查指标、微型营养评估精法(MNA-SF)及简易智能状态量表(MMSE)调查营养状况与认知功能,并分析之间的相关性。结果:AD组与正常老年人组比较,实验室检查指标及MNA-SF评分差异有统计学意义(P<0.05)。AD病人MNA-SF分值与MMSE分值呈显著正相关(r=0.59,P<0.05)。结论:AD病人营养不良的发生率很高,且与认知功能相互影响,在临床工作中应加强医护人员营养学知识的普及,加强AD病人的营养支持。

Objective： To investigate the relationship between nutritional status and cognitive function in patients with Alzheimer＇s disease （AD）, and to provide rationale for clinicians in nutrition intervention of AD patients. Methods： Sixty cases of elderly AD patients and 50 cases with normal elderly control were enrolled from the neurological department. Nutritional status and cognitive function were assessed using the laboratory parameters, mini nutritional assessment method （short -form Mini-Nutritional fine assessment, MNA-SF） and MMSE （Mini-Mental State, Examination, MMSE） survey. Results： Compared with control group, the AD group had significantly different laboratory index and MNA-SF score （P 〈 0.05）. MNA-SF scores were positively correlated with MMSE scores in patients with AD （r = 0.59, P 〈 0.05）. Conclusion： The incidence of malnutrition in AD patients is high, and it is related to their cognitive function. The nutritional knowledge should be strengthened among doctors and nurses treating patients with AD.