摘要
目的观察胃癌组织中性别决定基因相关HMG盒基因4(SOX4)和细胞核增殖抗原(Ki-67)的表达,探讨SOX4和Ki-67在胃癌组织表达的临床意义。方法采用免疫组织化学方法检测60例胃癌组织及60例其邻近正常胃组织中SOX4和Ki-67的表达,分析其在胃癌组织中的表达与临床病理特征间的关系。结果SOX4在胃癌组织中呈高表达,阳性表达率为71.7%(43/60),在正常胃组织中未见SOX4表达,Ki-67在胃癌组织中呈高表达,阳性表达率为86.7%(52/60),两者呈明显正相关(r=0.615, P=0.003);SOX4和Ki-67在胃癌组织中的表达与患者年龄、性别、肿瘤大小、浸润深度无明显相关(χ^2=0.056,P=0.821;χ^2=0.572,P=0.461;χ^2=0.131,P=0.882;χ^2=1.479,P=0.223;χ^2=0.652,P=0.482;χ^2=0.567,P=0.512;χ^2=0.545,P=0.652;χ^2=0.781,P=0.691),SOX4和Ki-67表达与肿瘤分化程度、淋巴结转移、TNM分期明显相关(χ^2=6.522,P=0.016;χ^2=7.681,P=0.005;χ^2=9.205,P=0.003;χ^2=6.761,P=0.012;χ^2=5.521,P=0.032;χ^2=5.857,P=0.017),SOX4和Ki-67在低分化、淋巴结转移、Ⅲ~Ⅳ期胃癌组织中的表达水平明显增高。结论SOX4和Ki-67在胃癌组织中呈高表达,参与胃癌的发生、发展,两者之间密切相关。
Objective To study the expression of sex determining region Y-box 4 (SOX4) and proliferation cell nuclear antigen (Ki-67) in gastric cancer and investigate the clinical significance with the expression of SOX4 and Ki-67 in gastric cancer.Methods Immunohistochemistry mothod was used to detect the expression of SOX4 and Ki-67 in gastric cancer in 60 gastric cancer tissues and 60 nearby normal gastric tissues, the relationship between the expression of SOX4, Ki-67 and the clinicopathological parameters was analyzed.Results The SOX4 highly express in the gastric cancer tissue and the positive rate of SOX4 expresssion in gastric cancer was 71.7% (43/60), no expression of SOX4 was detected in normal gastric mucosa.The Ki-67 highly express in gastric cancer in the gastric cancer tissue, and the positive rate of the Ki-67 expression in gastric cancer was 86.7% (52/60). Both the expression of SOX4 and the expression of Ki-67 in gastric cancer were positively associated (r=0.615, P=0.003); The expressions of SOX4, Ki-67 in gastric cancer were not related to the age, gender, tumor size and the tumor infiltration depth (χ^2=0.056, P=0.821; χ^2=0.572, P=0.461; χ^2=0.131, P=0.882; χ^2=1.479, P=0.223 and χ^2=0.652, P=0.482; χ^2=0.567, P=0.512; χ^2=0.545, P=0.652; χ^2=0.781, P=0.691). The expressions of SOX4 and Ki-67 were positively associated with histological differentiation, lymph node metastasis and clinical stage (χ^2=6.522, P=0.016; χ^2=7.681, P=0.005; χ^2=9.205, P=0.003 and χ^2=6.761, P=0.012; χ^2=5.521, P=0.032; χ^2=5.857, P=0.017)in gastric cancer.Conclusion SOX4 and Ki-67 were highly expressed in gastric cancer, they may play important roles in the tumorigenesis and progression of gastric cancer and there is a close relationship between them.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2018年第2期344-346,共3页
Chinese Journal of Experimental Surgery
基金
泉州市科技项目(B类)(Z[2014]0123)