甲状腺乳头状癌免疫逃逸机制进展

Progress in immune evasion mechanism of papillary thyroid cancer

甲状腺癌是人体最常见的内分泌恶性肿瘤，甲状腺癌在生成、发展、侵袭和转移的过程中与肿瘤细胞周围免疫微环境产生密切的联系，两者共同作用促使机体免疫功能耐受，进而逃避免疫监视。甲状腺癌临床上又以甲状腺乳头状癌最为常见。本文就甲状腺乳头状癌与肿瘤细胞周围免疫微环境的相互关系以及共同促使癌细胞免疫逃逸的机制进行综述，有助于为甲状腺乳头状癌的诊断和治疗提供新的思路。

Thyroid cancer is the most common endocrine malignant tumor of human hody. Thyroid cancer has close relationship with tumor cell surrounding immuno microenvironment in the process of formation, development, invade and metastasis. Their combined effect promotes body immune tolerance fires helps avoid from immune surveillance. Papillary thyroid cancer is the most common thy^vid tumor on clinical. This article focuses on the interaction of papillary thyroid cancer arid tumor cell surrounding immuno microenvironment, and the mechanism of their combined effeet promotes immune evasion of tumor cells, helps to find a new approach for the diagnose and therapy of papillary thyroid cancer.